Cancer Biology Training ProgramPotential Preceptors, Departmental Affiliation & Research
Department of Biochemistry & Molecular Biology:
Mark R. Kelley, Ph.D., Professor. Molecular and cellular biology and biochemistry of eukaryotic DNA base excision repair (BER) genes for basic science and translational applications to treat cancer and small molecule inhibitors of targeted DNA repair genes for anti-angiogenesis and tumor microenvironment therapies.
Reuben Kapur, Ph.D., Professor. Molecular genetics of normal and leukemic stem/progenitor cells
Murray Korc, M.D., Professor. Mouse models of pancreatic cancer . MicroRNA in pancreatic cancer. TGF-beta and EGFR in pancreatic cancer.
Harikrishna Nakshatri, B.V.Sc., Ph.D., Professor. Breast cancer biology; chemotherapy and anti-estrogen resistance, breast cancer stem cells and metastasis.
Lawrence Quilliam, Ph.D., Professor. Signaling via Ras, protein kinases and SH2/SH3 adaptor molecules in cancer.
John Turchi, Ph.D. Professor. Repair of chemotherapy induced DNA damage and DNA double strand break repair.
Zhong-Yin Zhang, Ph.D. Professor. Chemical biology, signaling mediated by tyrosine dephosphorylation, targeting protein tyrosine phosphatases for the treatment of cancer
Department of Dermatology
Elliot Androphy, M.D., Professor. Mechanism of human papillomavirus induced malignancies. Development of novel antiviral drugs. Mechanism of p53 tumor suppression.
Department of Medical and Molecular Genetics:
Rebecca Chan, M.D., Ph.D., Assistant Professor. The functional and biochemical role of several of the observed Shp-2 molecules in murine hematopoietic progenitor cell growth and cytokine response.
Brittney Shea-Herbert, Ph.D., Associate Professor. Genetics of aging and cancer; inherited breast/ovarian cancers; gene therapy; telomerase therapeutics
Bryan P. Schneider, M.D., Assistant Professor. Pharmacogenetics of breast cancer therapeutics
Department of Medicine
David A. Flockhart, M.D., Ph.D., Professor. Clinical Pharmacogenomics
Theresa Guise, M.D., Professor. Effects of cancer and cancer treatment on skeleton
Daniela Matei, M.D., Associate Professor. PDGFR signaling in cancer. Mechanisms of metastasis in ovarian cancer
David Roodman, M.D.,Ph.D., Professor. Role of bone cells in normal and pathologic conditions in particular myeloma.
Department of Microbiology & Immunology:
Janice S. Blum, Ph.D., Professor. Immune regulation; autoimmunity; biodefense; HLA; tumor and viral immunity; vaccines
Hal E. Broxmeyer, Ph.D., Distinguished Professor. Regulation of the self-renewal, survival, proliferation, differentiation and migration of hematopoietic, embryonic, and induced pluripotent stem cells, and hematopoietic progenitor cells; cytokine-cell interactions; intracellular signaling; in-vivo preclinical and clinical assessment; modulation by gene transfer/gene therapy
Randy R. Brutkiewicz, Ph.D., Professor. Inhibition of anti-tumor immunity by invariant natural killer T cells and manipulation of these events through gene transfer
D. Wade Clapp, M.D., Professor. Biochemical and phenotypic effects of heterozygous inactivation of NF1; regulation of hematopoiesis and mast cell production; neuorfibromatosis/NF1; gene transfer with retroviral, lentiviral, and foamy viral vectors
Chinghai Kao, Ph.D., Associate Professor. Gene therapy of prostate cancers
Mark H. Kaplan, Ph.D., Professor. Stat4 immunobiology; modulation of immune cell reactivity and function by transcription factors such as Stat 3,4, and 6
Department of Pharmacology and Toxicology:
Karen Pollok, Ph.D., Assistant Professor. Modulation of DNA repair activity in hematopoietic stem and progenitor cells (HSPC) with a focus on in vivo models to study protection of HSC from chemotherapy
Jian-Ting Zhang, Ph.D., Professor. Drug resistance in chemotherapy; signal transduction, translational control and cancer.