Funding Opportunities

NIH Funding Opportunities

Exploratory Clinical Trials of Novel Interventions for Mental Disorders (R33)
Funding Opportunity RFA-MH-16-400 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support the efficient pilot testing of novel interventions for mental disorders in adults and children through an experimental therapeutics approach.Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support go/no-go decisions about further development or testing of the intervention. Studies of novel interventions include, but are not limited to behavioral, pharmacological, biologics-based, cognitive, device-based, interpersonal, physiological, or combined approaches.Support will be provided for testing and validating the interventions ability to affect a specified target, and for relating the change in target to functional or clinical effects. Ultimately, this funding mechanism is intended to speed the translation of emerging basic science findings of mechanisms and processes underlying mental disorders into novel interventions that can be efficiently tested for their promise in restoring function and reducing symptoms for those living with mental disorders.
Mon, 30 Mar 2015 01:01:34 EST

Exploratory Clinical Trials of Novel Interventions for Mental Disorders (R21/R33)
Funding Opportunity RFA-MH-16-405 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support the efficient pilot testing of novel interventions for mental disorders in adults and children through an experimental therapeutics approach. Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support go/no-go decisions about further development or testing of the intervention. Studies of novel interventions include, but are not limited to behavioral, pharmacological, biologics-based, cognitive, device-based, interpersonal, physiological, or combined approaches. Support will be provided for up to two years (R21 phase) for preliminary milestone-driven testing and validating of the interventions therapeutic target, possibly followed by up to 3 years of support (R33 phase) for studies relating change in the intervention target to functional or clinical effects. Ultimately, this R21/R33 FOA is intended to speed the translation of emerging basic science findings of mechanisms and processes underlying mental disorders into novel interventions that can be efficiently tested for their promise in restoring function and reducing symptoms for those living with mental disorders.
Mon, 30 Mar 2015 01:01:28 EST

Pilot Effectiveness Trials for Treatment, Preventive and Services Interventions (R34)
Funding Opportunity RFA-MH-16-410 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to encourage pilot research consistent with NIMH's priorities for: 1) effectiveness research on preventive and therapeutic interventions with previously demonstrated efficacy, for use with broader target populations or for use in community practice settings, and 2) research on the development and preliminary testing of innovative services interventions. Applications should provide resources for evaluating the feasibility, tolerability, acceptability and safety of approaches to improve mental health or functional outcomes, or modify risk factors, and for obtaining the preliminary data needed as a pre-requisite to a larger-scale intervention trial (e.g., comparative effectiveness study, practical trial) or large-scale services study. In this pilot phase of effectiveness research, NIMH places highest priority on approaches that can be justified in terms of their potential to substantially impact practice and public health and approaches that are empirically grounded. Adaptations or augmentations of efficacious interventions should only be undertaken if there is an empirical rationale for the adaptation target and for the corresponding mechanism by which the adapted intervention or augmentation is expected to substantially enhance outcomes.This FOA is intended to support pilot effectiveness trials that are designed to explicitly address whether the intervention engages the target/mechanism that is presumed to underlie the intervention effects.
Mon, 30 Mar 2015 01:01:04 EST

Clinical Trials to Test the Effectiveness of Treatment, Preventive and Services Interventions (Collaborative R01)
Funding Opportunity RFA-MH-16-415 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to support collaborative research to test the therapeutic value of treatment, preventive, and services strategies for which there is already evidence of efficacy, for use in community and practice settings and to test hypotheses regarding moderators, mediators, and mechanisms of action of these interventions.This FOA supports research to evaluate the effectiveness of pharmacologic, psychosocial (psychotherapeutic and behavioral), rehabilitative and combination interventions that show promise, compared to existing treatment approaches, for improving symptomatic and functional outcomes for mental disorders. Studies that address either acute or longer-term therapeutic effects are encouraged.This FOA also supports clinical trials to test patient-, provider-, organizational-, or systems -level services interventions to improve service access, engagement, quality, coordination, or delivery, with the goal of improved outcomes for individual patients and as well as larger populations.The intervention research covered under this announcement is explicitly focused on practice-relevant questions.This FOA is intended to support research on interventions/services models that have the potential to substantially impact practice and public health in terms of the magnitude of likely improvements in key outcomes (e.g., clinical benefit, safety/tolerability profile, value and efficiency, or scalability potential), as compared to existing approaches.
Mon, 30 Mar 2015 01:01:41 EST

Clinical Trials to Test the Effectiveness of Treatment, Preventive, and Services Interventions (R01)
Funding Opportunity RFA-MH-16-420 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) seeks to support investigator-initiated clinical trials to establish the effectiveness of interventions and to test hypotheses regarding moderators, mediators, and mechanisms of action of these interventions. This FOA supports clinical trials designed to test the therapeutic value of treatment and preventive interventions for which there is already evidence of efficacy, for use in community and practice settings. Applications might include research to evaluate the effectiveness or increase the clinical impact of pharmacologic, somatic, psychosocial (psychotherapeutic, behavioral), device-based, rehabilitative and combination interventions to prevent or treat mental illness. This FOA also supports clinical trials to test patient-, provider-, organizational-, or systems -level services interventions to improve service access, engagement, quality, coordination, or delivery, with the goal of improved outcomes at the individual and population level. The intervention research covered under this announcement is explicitly focused on practice-relevant questions.
Mon, 30 Mar 2015 01:01:20 EST

Confirmatory Efficacy Clinical Trials of Non-Pharmacological Interventions for Mental Disorders (R01)
Funding Opportunity RFA-MH-16-425 from the NIH Guide for Grants and Contracts. The purpose of this Funding Opportunity Announcement (FOA) is to support confirmatory efficacy testing of non-pharmacological therapeutic and preventive interventions for mental disorders in adults and children through an experimental therapeutics approach. Under this FOA, trials must be designed so that results, whether positive or negative, will provide information of high scientific utility and will support "go/no-go" decisions about further development, effectiveness testing, or dissemination of the intervention. Intervention studies include, but are not limited to behavioral, cognitive, interpersonal, and device-based approaches, or a combination thereof. Interventions appropriate for efficacy testing must be based on a compelling scientific rationale, previous demonstration that the intervention engages and alters the hypothesized mechanism of action, a preliminary efficacy signal, and must address an unmet therapeutic need. Support will be provided for a trial of the intervention's efficacy that includes measurement of the hypothesized mechanism of action and the relationship between change in the mechanism and change in functional or clinical effects. Ultimately, this FOA is intended to support a sufficiently- powered efficacy trial to determine the intervention's potential for significant clinical benefit.
Mon, 30 Mar 2015 01:01:12 EST