Xin Lu, Ph.D.
109 Galvin Life Science Center
Notre Dame, IN 46556
Phone: (574) 631-6592
Research Program Membership
John M. and Mary Jo Boler Assistant Professor
University of Notre Dame
My main research goal is to develop novel insights into the genomic, genetic and molecular mechanisms of prostate tumor progression, tumor immunology and treatment resistance, and apply such knowledge to enhance efficacy of therapeutic intervention to benefit prostate cancer patients. My recent research is centered on mechanistic understanding of myeloid-derived suppressor cells (MDSCs) and developing strategies on targeting MDSCs to enhance immune checkpoint blockade. Most recently, I developed an efficient preclinical platform to test combinatorial immunotherapy for metastatic castration-resistant prostate cancer (mCRPC) and discovered that inactivating MDSCs can exert dramatic synergistic efficacy in treating mCPRC when combined with immune checkpoint blockade. In addition, my research program on prostate cancer functional genomics through in vivo ORF screen has identified new epigenetic regulatory mechanisms of prostate cancer bone metastasis and established a goldmine of new prostate cancer genes for deep mechanistic investigation and clinical translation. I am also interested in rare cancers and have developed the first transgenic mouse models of penile cancer. Continuation with deeper mechanistic understanding and translational application on the aforementioned lines of research represents the current and near future research interests of my laboratory at University of Notre Dame.
Post-doctoral Fellowship - Dana Farber Cancer Institute, Boston, MA 11/2011
Ph.D. - Princeton University, Princeton, NJ 07/20/10
Post-doctoral Fellowship - University of Texas MD Anderson Cancer Center, Houston, TX 04/2014