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Trial Summary

Protocol No.A011202
StatusOPEN TO ACCRUAL
Principal InvestigatorKorff, Lisa
ScopeNational
PhasePhase III
Age GroupAdult
TitleA Randomized Phase III Trial Comparing Axillary Lymph Node Dissection to Axillary Radiation in Breast Cancer Patients (cT1-3 N1) Who Have Positive Sentinel Lymph Node Disease After Neoadjuvant Chemotherapy
DescriptionThis randomized phase III trial studies lymph node dissection and radiation therapy to see how well it works compared to radiation therapy alone in treating patients with breast cancer previously treated with chemotherapy and surgery. Lymph node dissection may remove cancer cells that have spread to nearby lymph nodes in patients with breast cancer. Radiation therapy uses high-energy x-rays to kill tumor cells. It is not yet known if radiation therapy alone is as effective as lymph node dissection and radiation therapy together.
Key EligibilityIn order to be eligible to take part in this trial, patients must meet the following criteria:

  • Be 18 years of age or older
  • Have clinical stage T1-3 N1 M0 breast cancer at diagnosis
  • Have no inflammatory breast cancer
  • Must have no other malignancy with 5 years of registration with the exception of basal cell or squamous cell carcinoma of the skin
For a full list of eligibiliy criteria and additional trial information visit clinicaltrials.gov.
Applicable Disease SitesBreast Cancer
Participating InstitutionsIU Health Central Indiana Cancer Centers
  • CICC East
  • CICC Fishers
Indiana University (IU)
  • Eskenazi Hospital
  • IU Health Methodist Hospital
  • IU Health North (For use by Cancer Center CTO only)
  • IU Health West (For use by Cancer Center CTO only)
  • Indiana University Hospital / IU Simon Cancer Center
Treatment TypeTreatment
ContactXin Zhong, Phone: 317-274-5495
Pager: 317-312-2793
Email: zhongx@iupui.edu