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Trial Summary

Protocol No.MS200770-0001
StatusOPEN TO ACCRUAL
Principal InvestigatorDurm, Greg
ScopeNational
PhasePhase I
Age GroupAdult
TitleA Phase I, Open-label, Uncontrolled, Multicenter, Dose-escalation Study of M3541 in Combination with Palliative Radiotherapy in Subjects with Solid Tumors
DescriptionThis dose-escalation study will evaluate the safety, tolerability, pharmacokinetic (PK), pharmacodynamic, and signs of clinical efficacy of M3541 in combination with fractionated palliative radiotherapy (RT) in subjects with solid tumors with malignant lesions in the thorax, abdominal cavity, head and neck region, or extremities likely to benefit from palliative RT.
Key EligibilityIn order to be eligible to take part in this trial, patients must meet the following criteria:

  • Subjects must have solid tumors with malignant lesions in the thorax, abdominal cavity, head and neck region, or extremities (any histology) likely to benefit from palliative radiotherapy; subjects requiring palliative RT for lesions in the spine or lesions adjacent to the spinal cord are excluded from this study
  • Life expectancy >= 3 months
For a full list of participation criteria, please visit clinicaltrials.gov.
Applicable Disease SitesAny Site
Participating InstitutionsIndiana University (IU)
  • Indiana University Hospital / IU Simon Cancer Center
Treatment TypeTreatment
ContactAnne E. Younger, RNPhone: 317-274-0951
Pager: 317-312-1946
Email: anefoste@iupui.edu