Indiana University Melvin and Bren Simon Cancer Center

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Chemical GenomicsServices

The core’s services include:

 

• Consultation for assay development
• Assistance in assay implementation and validation
• Assistance in carrying out high-throughput screening of chemical libraries
• Access to chemical libraries (about 230,000 drug-like small molecules) pre-plated, readily available for screen in a 96- or 384-well format
• Training in the use of facility-maintained instrumentation
• Assistance with data analysis and compound selection
• Hit confirmation and follow-up
• Biophysical analysis

 

Types of assays implemented include:

 

• In vitro enzymatic activity assays
• In vitro protein binding assays
• Cell proliferation assays
• Cell-based reporter gene assays
• Whole cell-based phenotypic assays

 

Assay Detection capacity includes UV/Vis absorbance, fluorescence, fluorescence polarization (FP), time-resolved fluorescence (TRF), luminescence, AlphaScreen and LANCE (HTRF) technology.