Chemical GenomicsServices

The core’s services include:

 

  • Consultation for assay development
  • Assistance in assay implementation and validation
  • Assistance in carrying out high-throughput screening of chemical libraries
  • Access to chemical libraries (about 230,000 drug-like small molecules) pre-plated, readily available for screen in a 96- or 384-well format
  • Training in the use of facility-maintained instrumentation
  • Assistance with data analysis and compound selection
  • Hit confirmation and follow-up
  • Biophysical analysis

 

Types of assays implemented include:

 

  • In vitro enzymatic activity assays
  • In vitro protein binding assays
  • Cell proliferation assays
  • Cell-based reporter gene assays
  • Whole cell-based phenotypic assays

 

Assay Detection capacity includes UV/Vis absorbance, fluorescence, fluorescence polarization (FP), time-resolved fluorescence (TRF), luminescence, AlphaScreen and LANCE (HTRF) technology.