Indiana University Melvin and Bren Simon Cancer Center

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Stem Cell Transplant

The Stem Cell Transplant Core will support studies focused on murine and human stem cell biology and therapeutic applications. It provides IU Simon Cancer Center investigators with a state-of-the-art facility in which to perform in vivo studies in a timely and cost-effective manner. It provides specific breeding services, training and experimental consultation for three types of mouse colonies:

1. The B6.SJL-Ptrcspep3b/Boyj (BoyJ) mice will be used in murine transplantation experiments in which the relative repopulating ability of two genetically distinct sources of stem cells can be studied. The BoyJ mice express the CD45.1 cell surface antigen.
2. The NOD.CB17-Prkdcscid (NOD/SCID) and NOD.Cg-Prkdcscid IL2rgtm1Wjl/Sz (NS2) mice will be utilized in investigations focused on human stem/ progenitor cell biology and gene therapy. The NS2 mice are deficient in the common g chain receptor component. This blocks NK cell development and leads to additional defects in innate immunity (Shultz et al., 2005. JI 174: 6477). A Biosafety Level 2 (BSL2) facility is available for all studies using human cells. Extra training is required to work in this facility.