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Translational GenomicsServices

Services provided by the Translational Genomics Core Laboratory include:

For nucleic acid preparation, isolation, quantification and qualification (if applicable) of either formalin-fixed paraffin embedded (FFPE) or fresh tissue/cells.
For DNA, a range of activities from whole-genome genotyping to more focused studies using standard or custom single nucleotide polymorphism (SNP) performed on human samples. Results include clustering of samples, amplification and/or deletion of genes.
For RNA, gene expression profiling interrogates multiple whole-genomes or focused sets of target genes across large sample populations. The gene expression profiling can be performed on either human or mouse samples. For partially degraded RNA, cDNA-mediated Annealing, Selection, extension and Ligation (DASL) assay is performed to obtain mRNA level expression. Results include dandogram and fold expression difference of particular mRNA with user specified a-level or confidence interval. If investigators provide FFPE RNA to the core, the core pre-qualifies that the RNA provided is compatible with DASL assay.

If needed, samples can be stored in our facility for a specified period of time. At users’ request, the core provides raw data.