Member Biography
Joseph P. Bidwell Ph.D.
Associate Professor
Department of Anatomy and Cell Biology
School of Medicine
MS 5035
635 Barnhill Dr.
Indianapolis, IN 46202
Phone: (317) 278-1142
Research Program Membership
Affiliate Member
Research Interests
The nuclear matrix proteins, NP/NMP4, are a family of zinc finger/AT-hook proteins that are distinct products of the same rat gene, bind to the rat type I collagen a1(I) polypeptide chain (COL1A1) promoter in the manner of an architectural transcription factor, and regulate promoter activity (Alvarez et al., 1998, 1997; Thunyakitpisal et al., in review). We are studying the role of these proteins, and other nuclear matrix proteins, in mediating the anabolic response of bone to parathyroid hormone and mechanical load.
Publications
Education
Post-doctoral Fellowship University of Massachusetts Medical Center, Worcester, MA 1990-1993
Post-doctoral Fellowship Columbia University/Howard Hughes Medical Institute at the Marine Biological Laboratory and the Woods Hole Oceanographic Institution, Woods Hole, MA 1983-1988
Ph.D. Case Western Reserve University, Cleveland, OH 1983