The Breast Cancer Program is a highly interactive one that has members from 11 departments of the IU School of Medicine as well Medical Sciences and Chemistry Departments at IU-Bloomington. The program includes both basic investigators and clinicians so that laboratory findings can be transferred quickly to the clinic. The program seeks to:
- understand the biology underlying breast cancer,
- apply our understanding of breast cancer biology to improve prevention, diagnosis, and treatment, and
- foster research that is interdisciplinary and translational in nature.
To identify the molecular, biochemical and physical events that underlay the development and maintenance of breast cancer and to apply these findings to enhance the prevention, diagnosis and treatment of the disease requires a multidisciplinary approach encompassing basic science and clinical expertise.
The program has a strong team of investigators that span the clinical translation arena, structural biology, gene expression, pathology, animal models, proteomics, genomics, biostatistics and bioinformatics, and are recognized in their respective fields. Together, these investigators unite multiple areas of expertise to efficiently identify and dissect complex cellular profiles leading to new insights into breast cancer biology and their ultimate translation to the clinic.
Program investigators are united under four themes: cell signaling pathway alterations, angiogenesis and therapeutic anti-angiogenesis approaches, genomic damage and repair mechanisms, and therapeutic individualization.