Walther Hall
Joseph E. Walther Hall, Indiana University’s largest research building, houses most of the cancer center’s researchers.

The Indiana University Melvin and Bren Simon Cancer Center is one of the leading academic cancer research centers in the United States. It is located in Indianapolis on the IU School of Medicine campus.

Indianapolis canal and skyline
Indianapolis, America's 14th largest city, is home to the IU Simon Cancer Center. The cancer center is one of only 51 National Cancer Institute-designated Comprehensive Cancer Centers in the country.

At the IU Simon Cancer Center, more than 200 scientists conduct research from four different programs.  The goals of those programs range from understanding the molecular changes that cause cancer to developing targeted therapies to prevent and treat cancer.

Each year, IU Simon Cancer Center physician-scientists lead hundreds of clinical trials for pediatric and adult cancers.

Our researchers have made discoveries that have changed the way doctors treat testicular cancer, breast cancer, gastrointestinal cancer, genitourinary cancer, leukemia, multiple myeloma, thymoma and thymic carcinomas, and thoracic cancer.

The researchers at the IU Simon Cancer Center are primarily faculty of the IU School of Medicine. They also include researchers from the IU School of Nursing and the IU Richard M. Fairbanks School of Public Health at IUPUI among other schools.

A National Cancer Institute-Designated Cancer Center

The IU Simon Cancer Center is Indiana’s only National Cancer Institute (NCI)-designated Comprehensive Cancer Center, one of only 51 in the nation. The NCI-designated cancer centers are recognized for meeting rigorous criteria for world-class, state-of-the-art programs in multidisciplinary cancer research. These centers put significant resources into developing research programs, faculty and facilities that will lead to better approaches to prevention, diagnosis and treatment of cancer. The NCI designation not only recognizes excellence but opens doors to greater federal funding, information sharing and resources.

Our Partnership with IU Health

Through our partnership with Indiana University Health, cancer patients benefit from the scientific discoveries made at the IU Simon Cancer Center. IU Health provides multidisciplinary clinical care for adults with cancer at IU Health Simon Cancer Center and for children at Riley Hospital at IU Health.

Many IU Simon Cancer Center researchers are both scientists and physicians. Search our member directory to find physician scientists working in a particular research area.

For the Next Generation of Cancer Researchers

At the IU Simon Cancer Center, you will see how scientific discoveries change the way physicians deliver cancer care. Learn about educational opportunities at the IU Simon Cancer Center » 

Our history

1992: The National Cancer Institute (NCI) awards a planning grant to the IU School of Medicine for a cancer center, establishing the Indiana University Cancer Center.

1999: The IU Cancer Center earns National Cancer Institute designation.

2004: NCI renews designation.

2006: The IU Cancer Center becomes the Indiana University Melvin and Bren Simon Cancer Center to reflect the philanthropic support of Melvin and Bren Simon.

2008: NCI renews designation.

2014: NCI renews designation.

2019: The IU Simon Cancer Center earns Comprehensive Cancer Center status, the NCI’s highest designation.