The overall goal for the Indiana Genitourinary Cancers Research Consortium is to translate basic science findings into the clinical setting by identifying novel therapeutic targets and strategies for the prevention and treatment of bladder, kidney, prostate and testicular cancer. The program is a collaborative effort between the Purdue University Center for Cancer Research and the IU Simon Cancer Center. Scientific goals: The scientific goals of the program are advanced by focused work in three themes:

Theme 1: Genetic and epigenetic signatures

Aim 1: To identify genetic and epigenetic alterations in rare histological variants

Aim 2: To identify epigenetic adaptation as resistance mechanism to targeted therapies

Theme 2: Tumor microenvironment

Aim 1: To dissect stem cell biology

Aim 2: To characterize tumor/stroma interactions in the metastatic niche

Aim 3: To determine the role of myeloid suppressive cells and macrophages in response to immunotherapies

Theme 3: Novel therapeutic strategies

Aim 1: To design rational combinations with epigenetic therapies

Aim 2: To develop immunomodulators

Aim 3: To develop receptor-mediated targeted therapies   

Aim 4: To conduct phase I/II clinical investigator-initiated clinical trials for bladder, kidney, prostate and testicular cancer