Fabiana Perna, M.D., Ph.D.
980 W. Walnut St.
IB 544 C
Indianapolis, IN 46202
Research Program Membership
Dr. Perna's research interests include:
The goal of the Perna lab is to develop precision immunotherapy by investigating the cancer cell surface proteome. By mining composite high-throughput expression data in genetic models and primary patient samples with a pipeline that Dr. Perna established for Chimeric Antigen Receptor (CAR) target discovery, targets identified will be integrated into a personalized therapeutic platform, taking into account patient genetic mutational background. The lab has an expertise in virally expressing key genetic and epigenetic mutations in primary cells and performing large scale multiomic studies, including cell surface-specific proteomic studies followed by label-free and multiplexed targeted Mass-Spectrometry analysis, single-cell RNA-seq analysis and human xenograft in immune-deficient mice. We want to investigate how essential genetic and epigenetic determinants of hematologic malignancies shape the cell surfaceome, thus providing targets for promoting leukemogenesis and use of precision immunotherapy.
Fellowship - Memorial Sloan Kettering Cancer Center, New York, NY 2019
Ph.D. - Memorial Sloan Kettering Cancer Center, New York, NY 2013
Residency - Federico II University, Naples, Italy 2009
M.D. - Federico II University, Naples, Italy 2004