Teresa Zimmers, Ph.D.
980 W. Walnut St.
Walther Hall, R3 C518
Indianapolis, IN 46202
Phone: (317) 278-7289
Research Program Membership
Dr. Zimmers's research interests include:
Research Interests of Teresa Zimmers's Cachexia/Euhexia Laboratory: >> The overall aim of my research is to understand the molecular mechanisms regulating systemic consequences of cancer and other chronic disease. The model system and application we have chosen to study is regulation of skeletal muscle mass. Muscle size is highly plastic and extraordinarily responsive to changes in single genes or pathways. Furthermore, skeletal muscle protein stores and metabolic functions play important and essential roles in the physiologic response to injury and disease. We seek to discover the molecular pathways regulating muscle plasticity in the setting of serious illness. My current research is directed at defining the roles of different signaling pathways, IL-6/STAT3, myostatin/ACVR2/SMAD pathway, and other developmental pathways in skeletal muscle wasting in cancer and burn injury. These are bench lab projects involving cell culture, mouse models and bioinformatics approaches. The major translational thrust of the lab at this time is to begin to understand human cachexia due to pancreatic cancer by defining the clinical and molecular changes in blood, fat and muscle due to the tumor. My discovery efforts are aimed at integrating these projects, identifying novel modulators of muscle size and defining the transcriptional cascades involved in muscle growth regulation. The long term goal is to develop targeted interventions for muscle preservation in chronic disease. Current Research Projects IL-6 family ligands and STAT3 signaling in muscle wasting of cancer and burn Myostatin family ligands and ACVR/SMAD signaling in cancer and burn cachexia Molecular phenotyping of pancreatic cancer cachexia The role of protein redistribution in the pathobiology of injury and muscle wasting
Post-doctoral Fellowship - University of Rochester School of Medicine, Rochester, NY 2003
Ph.D. - The Johns Hopkins University School of Medicine, Baltimore, MD 2001